Suppression of natural killer (NK) cell activity of spleen cells by thymocytes

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Suppression of natural killer (NK) cell activity of spleen cells by thymocytes.

The in vitro influence of thymus cells on natural killer cell activity of spleen cells against prelabeled target cells (YAC-I and RLbI) has been studied in syngeneicas well as in allogeneic murine models. In mixing experiments to demonstrate suppression, total thymocytes have been found to have no effect on NK activity of syngeneic or allogeneic spleen cells. Among several thymocyte fractions s...

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We and others have found that the functions of hepatic natural killer (NK) cells are inhibited but invariant NKT (iNKT) cells become activated after alcohol drinking, leaving a possibility that there exists interplay between NK cells and iNKT cells during alcoholic liver disease. Here, in a chronic plus single-binge ethanol consumption mouse model, we observed that NK cells and interferon-γ (IF...

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ژورنال

عنوان ژورنال: Cellular Immunology

سال: 1981

ISSN: 0008-8749

DOI: 10.1016/0008-8749(81)90144-1